MOEを使用した論文の一覧です。研究の参考にご利用下さい。
（現在弊社で把握しているものであり、MOEを使用した論文の全てを掲載しているわけではありません。
論文を出版された方、一覧に掲載されていない論文をご存知の方は、こちらまでお知らせいただけましたら幸いです。）

• MOEを使用した論文
• 弊社製MOEアドオンプログラムASEDockを使用した論文
• 弊社製MOEアドオンプログラムAutoQSARを使用した論文

また、CCG社のMOE Citationsページもご参照ください。

1. Amari, S.; Aizawa, M.; Zhang, J.; Fukuzawa, K.; Mochizuki, Y.; Iwasawa, Y.; Nakata, K.; Chuman, H.; Nakano, T. VISCANA: Visualized Cluster Analysis of Protein-Ligand Interaction Based on the ab Initio Fragment Molecular Orbital Method for Virtual Ligand Screening,J. Chem. Inf. Model., 2006, 46, 221-230.
2. Arakawa, M.; Hasegawa, K.; Funatsu, K. Tailored scoring function of Trypsin-benzamidine complex using COMBINE descriptors and support vector regression,Chemom. Intell. Lab. Syst., 2008, 92, 145-151.
3. Auzanneau, F.-I.; Sourial, E.; Schmidt, J.M.; Feher, M. Stochastic conformational search on the Lewis X (Le^x) trisaccharide and three Le^x analogues,Can. J. Chem., 2002, 80, 1088-1095.
4. Azuma, M.; Kabe, Y.; Kuramori, C.; Kondo, M.; Yamaguchi, Y.;, Handa, H. Adenine Nucleotide Translocator Transports Haem Precursors into Mitochondria,PLoS ONE, 2008, 3, e3070.
5. Bai, J.-Y.; Ding, W.-G.; Kojima, A.; Seto, T.; Matsuura, H.. Putative binding sites for arachidonic acid on the human cardiac Kv1. 5 channelBritish journal of pharmacology, Wiley Online Library, 2015, Vol. 172(22), pp. 5281-5292
6. Bajorath, J.. Selected concepts and investigations in compound classification, molecular descriptor analysis, and virtual screening.J. Chem. Inf. Comput. Sci., 2001, 41, 233-245.
7. Baraldi, P.G.; Cacciari, B.; Moro, S.; Spalluto, G.; Pastorin, G.; Da Ros, T.; Klotz, K.-N.; Varani, K.; Gessi, S.; Borea, P. A.. Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists,J. Med. Chem., 2002, 45, 770-780.
8. Baraldi, P.G.; Cacciari, B.; Romagnoli, R.; Spalluto, G.; Moro, S.; Klotz, K.-N.; Leung, E.; Varani, K.; Gessi, S.; Merighi, S.; Borea, P.A.. Pyrazolo [4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selection human A(3) adenosine receptor antagonists: Influence of the chain at the N(8) pyrazole nitrogen,J. Med. Chem., 2000, 43, 4768-4780.
9. Baudry, J.; Li, W.; Pan, L.; Berenbaum, M.R.; Schuler, M.A.. Molecular docking of substrates and inhibitors in the catalytic site of CYP6B1, an insect cytochrome P450 monooxygenase, Protein Eng., 2003, 16, 577-587.
10. Baurin, N.; Mozziconacci JC.; Arnoult, E.; Chavatte, P; Marot, C.; Morin-Allory, L.. 2D QSAR Consensus Prediction for High-Throughput Virtual Screening. An Application to COX-2 Inhibition Modeling and Screening of the NCI Database, J. Chem. Inf. Comput. Sci., 2004, 44, 276-285.
11. Cen, X.; Nitta, A.: Ohya, S.; Zhao, Y.; Ozawa, N.;, Mouri, A.; Ibi, D.; Wang, L.; Suzuki, M.; Saito, K.; Ito, Y.; Kawagoe, T.; Noda, Y.; Ito, Y.; Furukawa, S.; Nabeshima, T.. An Analog of a Dipeptide-Like Structure of FK506 Increases Glial Cell Line-Derived Neurotrophic Factor Expression through cAMP Response Element-Binding Protein Activated by Heat Shock Protein 90/Akt Signaling Pathway,J. Neurosci., 2006, 26, 3335-3344.
12. Chen. R.; Yokoyama, M.; Sato, H.; Reilly, C.; Mansky, L.M.. Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodefiency Virus Type 1 Mutation Frequencies, J. Virol., 2005, 79, 12045-12057.
13. Chou. K.-C.; Howe, W.J. Prediction of the tertiary structure of the beta-secretase zymogen. Biochemical and Biophysical Research Communications, 2002, 292, 702-708.
14. Daines, R.A.; Pendrak, I.; Sham, K.; Van Aller, G.S.; Konstantinidis, A.K.; Lonsdale, J.T.; Janson, C.A.; Qiu, X.; Brandt, M.; Khandekar, S.S.; Silverman, C.; Head, M.S.. First x-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling. J. Med. Chem., 2003, 46, 5-8.
15. Demura, M.; Yoshida, T.; Hirokawa, T.; Kumaki, Y.; Aizawa, T.; Nitta, K.; Bitter, I.; Toth ,K.. Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system, Bioorg. Med. Chem. Lett., 2005, 15, 1367-1370.
16. Ding Y.; Wang L.; Liu B.; Ren G.; Okubo R.; Yu J.; Zhang C.. Bryodulcosigenin attenuates bleomycin-induced pulmonary fibrosis via inhibiting AMPK-mediated mesenchymal epithelial transition and oxidative stress, Phytother. Res., 2022, 36(10), 3911-3923.
17. Duffy, K.J.; Shaw, A.N.; Delorme, E.; Dillon, S.B.; Erickson-Miller, C.; Giampa, L.; Huang, Y.; Keenan, R.M.; Lamb, P.; Liu, N.; Miller, S.G.; Price, A.T.; Rosen, J.; Smith, H.; Wiggall, K.J.; Zhang, L.; Luengo, J.I.. Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics, J. Med. Chem., 2002, 45, 3573-3575.
18. Duffy, K.J.; Price, A.T.; Delorme, E.; Dillon, S.B.; Duquenne, C.; Erickson-Miller, C.; Giampa, L.; Huang, Y.; Keenan, R.M.; Lamb, P.; Liu, N.; Miller, S.G.; Rosen, J.; Shaw, A.N.; Smith, H.; Wiggall, K.J.; Zhang, L.; Luengo, J.I.. Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d] imidazole thrombopoietin mimics, J. Med. Chem., 2002, 45, 3576-3578.
19. Ermondi, G.; Caron, G.; Lawrence, R.; Longo, D.. Docking studies on NSAID/COX-2 isozyme complexes using Contact Statistics analysis.J. Comput. Aided. Mol. Des., 2004, 18, 683-696.
20. Esposito, E.X.; Baran, K.; Kelly, K.; Madura, J.D.. Docking of sulfonamides to carbonic anhydrase II and IV.J. Molec. Graph. and Mod., 2000, 18, 283-289.
21. Esposito, E.X.; Baran, K.; Kelly, K.; Madura, J.D.. Docking substrates to metalloenzymes.Molecular Simulation, 2000, 24, 293-306.
22. Feher, M.; Schmidt, J.M.. Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry, J. Chem. Inf. Comput. Sci., 2003, 43, 218-227.
23. Feher, M.; Schmidt, J. Metric and multidimensional scaling: Efficient tools for clustering molecular conformations,J. Chem. Inf. Comput. Sci., 2001, 41, 346-353.
24. Feher, M.; Schmidt, J.M.. Multiple flexible alignment with SEAL: A study of molecules acting on the colchicine binding site,J. Chem. Inf. Comput Sci. , 2000, 40, 495-502.
25. Feher, M.; Sourial, E.; Schmidt, J.M.. A simple model for the prediction of blood-brain partitioning. Int. J. Pharmaceutics, 2000, 201, 239-247.
26. Fukiage, C.; Nakajima, E.; Ma, H.; Azuma, M.; Shearer, T.R.. Charaterization and regulation of lens-specific calpain Lp82, J. Biol. Chem., 2002, 277, 20678-20685.
27. Fukuhara, T.; Kobayashi, K.; Kanayama, Y.; Enomoto, S.; Kondo, T.; Tsunekawa, N.; Nemoto, M.; Ogasawara, N.; Inagaki, K.; Tamura, T.. Identification and characterization of the zosA gene involved in copper uptake in Bacillus subtilis 168, Bioscience, Biotechnology, and Biochemistry, 2016, 80, 600-609.
28. Gagnon, L.; DiMarco, M.; Kirby, R.; Zacharie, B.; Penney, C.L.. D-LysAsnProTyr tetrapeptide: a novel B-cell stimulant and stabilized bursin mimetic, Vaccine, 2000, 18, 1886-1892.
29. Gao, H. Application of BCUT metrics and genetic algorithm in binary QSAR analysis,J. Chem. Inf. Comput. Sci., 2001, 41, 402-407.
30. Gao, H.; Williams, C.; Labute, P; Bajorath, J.
    Binary quantitative structure – activity relationship (QSAR) analysis of estrogen receptor ligands.J. Chem. Inf. Comput. Sci., 1999, 39, 164-168.
31. 「基礎と実習　バイオインフォマティクス」郷通子、高橋健一　編、2004, 共立出版（株）
32. Godden, J.W.; Furr, J.R.; Bajorath, J.Recursive median partitioning for virtual screening of large databases, J. Chem. Inf. Comput. Sci., 2003, 43, 182-188.
33. Godden, J.W.; Bajorath, J.. Chemical Descriptors with Distinct Levels of Information Content and Varying Sensitivity to Differences between Selected Compound Databases Identified by SE-DSE Analysis,J. Chem. Inf. Comput. Sci., 2002, 42, 87-93.
34. Godden, J.W.; Xue, L.; Kitchen, D.B.; Stahura, F.L.; Schermerhorn, E.J.; Bajorath, J. Median partitioning.. A novel method for the selection of representative subsets from large compound pools, J. Chem. Inf. Comput. Sci. , 2002, 42, 885-893.
35. Godden, J.W.; Stahura, F.L.; Bajorath, J.. Variability of molecular descriptors in compound databases revealed by shannon entropy calculations, J. Chem. Inf. Comput. Sci., 2000, 40, 796-800.
36. Godden, J.W.; Xue, L.; Bajorath, J.. Combinatorial preferences affect molecular similarity/diversity calculations using binary fingerprint and Tanimoto coefficients,J. Chem. Inf. Comput. Sci., 2000, 40, 163-166.
37. Goto, J.; Kataoka, R.; Hirayama, N.. Ph4Dock: Pharmacophore-Based Protein-Ligand Docking. J. Med. Chem., 2004, 47, 6804-6811.
38. Goto, J.; Kataoka, R.; Muta H.; Hirayama, N.. ASEDock-Docking Based on Alpha Spheres and Excluded Volumes. J. Chem. Inf. Model., 2008, 48, 583-590.
39. Giuliano, B.; Clayton, S.; Nigel, J., W.; Franco, L.. In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data Set. J. Med. Chem., 2009, 52, 4488-4495.
40. Hashimoto, M.; Taguchi, T.; Ishikawa, K.; Mori, R.; Hotta, A.; Watari, S.; Katakawa, K.; Kumamoto, T.; Okamoto, S.; Ichinose, K.. Unveiling Two Consecutive Hydroxylations: Mechanisms of Aromatic Hydroxylations Catalyzed by Flavin-Dependent Monooxygenases for the Biosynthesis of Actinorhodin and Related Antibiotics, ChemBioChem 2019, 20, 1-6.
41. Hamada T, Kawashima M, Watanabe H, Tagami J, Senpuku H.. Molecular interactions of surface protein peptides of Streptococcus gordonii with human salivary components.Infect. Immun. 2004, 72(8), 4819-26.
42. Hasegawa, K.; Koyama, M.; Funatsu, K.. Quantitative Prediction of Regioselectivity Toward Cytochrome P450/3A4 Using Machine Learning Approaches.
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43. Hasegawa, K.; Funatsu, K.. Advanced PLS Technique Focusing on Visualization and Chemical Interpretation – SOMPLS Analysis of Serine Protease Inhibitors -.
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44. Hashimoto, M.; Watari, S.; Taguchi T.; Ishikawa K.; Kumamoto T.; Okamoto S.; Ichinose K.. Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction. Angew. Chem., Int. Ed. 2022, https://doi.org/10.1002/anie.202214400
    

45. Hidaka, K.; Kimura, T.; Abdel-Rahman, H., M.; Nguyen, J.-T.; McDaniel, K., F.; Kohlbrenner, W., E.; Katsuki, N.; Tanaka, Y.; Matsumoto, H.; Wang, J.; Hayashi, Y.; Kempf, D., J.; Kiso, Y.. Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S₂‘ Pocket. J. Med. Chem., 2009, 52, 7604-7617.
46. Howarth, N.M.; Purohit, A.; Robinson, J.J.; Vicker, N.; Reed, M.J.; Potter, B.V.L.. Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: Homology model construction and docking studies, Biochemistry, 2002, 41, 14801-14814.
47. Huang, J.; Hamasaki, T.; Ozoe, F.; Ohta, H.; Enomoto, K.; Kataoka, H.; Sawa Y.; Hirota, A.; Ozoe, Y.. Identification of Critical Structural Determinants Responsible for Octopamine Binding to the R-Adrenergic-like Bombyx mori Octopamine Receptor. Biochemistry, 2007, 46, 5896-5903.
48. Ishii, K.; Kondo, K.; Takahashi, M.; Kimura M.; Endoh, M.. An amino acid residue whose change by mutation affects drug binding to the HERG channel,FEBS Letters, 2001, 506, 191-195.
49. Ito, S.; Nakahari, T.; Yamamoto, D.. The structural feature surrounding glycated lysine residues in human hemoglobin,Biomed. Res.,2011,32.217-223.
50. Ito, S.; Nakahari, T.; Yamamoto, D.. Relationship between impaired glycation and the N-terminal structure of the Hb G¥örwihl [$5 (A2) Pro->Ala] variant,Hemoglobin,2010,34.151-156.
51. Ito, S.; Yamamoto, D.. Identification of two bromocresol purple binding sites on human serum albumin, Clin. Chim. Acta, 2010,411.1536-1538.
52. 片岡良一、後藤純一「バイオインフォマティクスと創薬」ポストシークエンスタンパク質実験法 1ー全タンパク質の解析ー 大島泰郎、鈴木紘一、藤井義明、村松喬　編、p191-201、 2002,（株）東京化学同人
53. 片岡良一、後藤純一ASEDock—結合部位の形状に基づくドッキングMolecular Science, 2008, 2, NP008.
54. Kataoka, R.; Amari, S.; Ikegami, T.; Hirayama, N. HLABAP: HLA Class I-Binding Antigenic Peptide Predictor, CBIJ., 2020, 20, 1-4.
55. Katada, S.; Hirokawa, T.; Oka, Y.; Suwa, M.; Touhara, K.. Structural Basis for a Broad But Selective Ligand Spectrum of a Mouse Olfactory Receptor: Mapping the Odorant-Binding Site, J. Neurosci., 2005, 25, 1806-1815.
56. Kinomoto, M.; Yokoyama, M.; Sato, H.; Kojima, A.; Kurata, T.; Ikuta, K.; Sata, T.; Tokunaga, K.. Amino Acid 36 in the Human Immunodeficiency Virus Type 1 gp41 Ectodomain Controls Fusogenic Activity: Implications for the Molecular Mechanism of Viral Escape from a Fusion Inhibitor,J. Virol., 2005, 79, 5996-6004.
57. Kinomoto, M.; Appiah-Opong, R.; Brandful, J.A.M.; Yokoyama, M.; Nii-Trebi, N.; Ugly-Kwame, E.; Sato, H.; Ofori-Adjei, D.; Kurata, T.; Barre-Sinoussi, F.O.; Sata, T.; Tokunaga, K.. HIV-1 proteases from drug-na ve West African patients are differentially less susceptible to protease inhibitors,
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58. Kiso, A.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Nezami, A.; Freire, E.; Kiso, Y.. Search for substrate-based inhibitors fitting the S2′ space of malarial aspartic protease plaasmepsin II, J. Peptide Sci., 2004, 10, 641-647.
59. Kobayashi, K.; Oishi, S.; Hayashi, R.; Tomita, K.; Kubo, T.; Tanahara, N.; Ohno, H.; Yoshikawa, Y.; Furuya, T.; Hoshino, M.; Fujii, N.. Structure-Activity Relationship Study of a CXC Chemokine Receptor Type 4 Antagonist, FC131, Using a Series of Alkene Dipeptide Isosteres, Journal of Medicinal Chemistry,2012,55.2746-2757.
60. Kojima, A.; Fukushima, Y.; Ito, Y.; Ding, WG.; Ueda, R.; Seto, T.; Kitagawa, H.; Matsuura, H.. Interactions of propofol with human voltage-gated Kv1.5 channel determined by docking simulation and mutagenesis analyses, J Cardiovasc Pharmacol, 2018, 71, 10-18.
61. Kotake, T.; Hayashi, Y.; Rajesh, S.; Mukai, Y.; Takiguchi, Y.; Kimura, T.; Kiso, Y.. Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reaction,Tetrahedron, 2005, 61, 3819-3833.
62. Kubo, Y.; Yokoyama, M.; Yoshii, H.; Mitani, C.; Tominaga, C.; Tanaka, Y.; Sato, H.; Yamamoto, N.. Inhibitory role of CXCR4 glycan in CD4-independent X4-tropic human immunodeficiency virus type 1 infection and its abrogation in CD4-dependent infection, J. Gen. Virol., 2007, 88, 3139-3144.
63. Kurotsuchi A.; Murakumo Y.; Jijiwa M.; Kurokawa K.; Itoh Y.; Kodama Y.; Kato T.; Enomoto A.; Asai N.; Terasaki H.; Takahashi M.. Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells, Cancer Sci., 2010, 101, 1147-1155.
64. Labute, P.; Nilar, S.; Williams, C.. A Probabilistic Approach to High Throughput Drug Discovery,Combinatorial Chemistry & High Throughput Screening, 2002, 5, 135-145.
65. Labute, P.; Williams, C.; Feher, M.; Sourial, E.; Schmidt, J.M.. Flexible alignment of small molecules,J. Med. Chem., 2001, 44, 1483-1490.
66. Labute, P.. A widely applicable set of descriptors, J. Mol. Graphics Mod. , 2000, 18, 464-477.
67. Li, X.; Baudry, J; Berenbaum, M.R.; Schuler, M.A.. Structural and functional evolution of insect CYP6B proteins: from specialist to generalist P450,Proc. Natl. Acad. Sci. , 2004, 101, 2939-2944.
68. Lindstrom, A.; Pettersson, F; Almqvist, F; Berglund, A.; Kihlberg, J.; Linusson, A.. Hierarchical PLS Modeling for Predicting the Binding of a Comprehensive Set of Structurally Diverse Protein-Ligand Complexes, J. Chem. Inf. Model. , 2006, 46, 1154-1167.
69. Maeda, M.H.; Toda, K.; Kaga, A.. Novel Soybean Variety Lacking Raffinose Synthase 2 Activity, ACS Omega, 2024, 9, 2134-2144.
70. Manavalan, B.; Murugapiran, S.K.; Lee, G.; Choi, S.. Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetases. BMC Struct. Biol., 2010, 10:1.
71. Meagher, K. L.; Lerner, M. G.; Carlson, H. A.. Refining the Multiple Protein Structure Pharmacophore Method: Consistency across Three Independent HIV-1 Protease Models, J. Med. Chem., 2006, 49, 3478-3484.
72. Misumi, S.; Endo, M.; Mukai, R.; Tachibana K.;Umeda M.; Honda, T.,Takamune, N.; Shoji, S.. A Novel Cyclic Peptide Immunization Strategy for Preventing HIV-1/AIDS Infection and Progression, J. Biol. Chem. , 2003, 278, 32335-32343.
73. Motomura, K.; Oka, T.; Yokoyama, M.; Nakamura, H.;Mori, H.; Ode, H.; Hansman, GS.; Katayama, K.; Kanda, T.; Tanaka, T.; Takeda, N.; Sato, H.. the Norovirus Surveillance Group of Japan: Identification of Monomorphic and Divergent Haplotypes in 2006/2007 Norovirus GII/4 Epidemic Population by Genome-wide Tracing of Evolutionary History, J. Virol., 2008, 82, 11247-11262.
74. Murayama, N.; Imai, N.; Nakane, T.; Shimizu, M.;Yamazaki, H.. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes, Biochem. Pharmacol. , 2007, 73, 2020-2026.
75. Nagata, N.; Iwata, N.; Hasegawa, H.; Fukushi, S.; Yokoyama, M.; Harashima, A.; Sato, Y.; Saijo, M.; Morikawa, S.; Sata, T.. Participation of both host and virus factors in induction of severe acute respiratory syndrome in F344 rats infected with SARS coronavirus, J. Virol., 2007, 81, 1848-1857.
76. Naganawa, S.; Yokoyama, M.; Shiino, T.; Suzuki, T.; Ishigatsubo, Y.; Ueda, A.; Shirai, A.; Takeno, M.; Hayakawa, S.; Sato, S.; Tochikubo, O.; Kiyoura, S.; Sawada, K.; Ikegami, T.; Kanda, T.; Kitamura, K.; Sato, H.. Net Positive Charge of HIV-1 CRF01_AE V3 Sequence Regulates Viral Sensitivity to Humoral Immunity, PLoS ONE, 2008, 3, e3206.
77. Nayeem, A.; Sitkoff, D.; Krystek, S., Jr.. A comparative study of available software for high-accuracy homology modeling: From sequence alignments to strucutural models, Protein Science., 2006, 15, 808-824.
78. Nishigaya, Y.; Fujimoto, Z.; Yamazaki, T.. Optimized inhibition assays reveal different inhibitory responses of hydroxylamine oxidoreductases from beta- and gamma-proteobacterial ammonium-oxidizing bacteria, Biochem Biophys Res Commun., 2016, 476, 127-133.
79. 西ヶ谷有輝、土屋渉、藤本瑞、鈴木倫太郎、山崎俊正「構造ベース創農薬による硝化抑制剤の開発～農薬開発に必要なイノベーション～」日本農薬学会誌, 2019, 44(1), 44-51.
80. Nishioka, T.; Endo-Umeda, K.; Ito, Y.; Shimoda, A.; Takeuchi, A.; Tode, C.; Hirota, Y.; Osakabe, N.; Makishima, M.; Suhara, Y.. Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives, Molecules, 2019, 24, 4316.
81. Niwa, T.; Asaki, T.; Kimura, S.. NS-187 (INNO-406), a Bcr-Abl/Lyn Dual Tyrosine Kinase Inhibitor, Analytical Chemistry Insights., 2007, 2, 93-106.
82. Ogola, H., J., O.; Kamiike, T.; Hashimoto, N.; Ashida H.; Ishikawa T.; Shibata H.; Sawa Y.. Molecular characterization of a novel peroxidase from the cyanobacterium Anabaena sp. strain PCC 7120. Applied and Environmental Microbiology, 2009, 75, 7509-7518.
83. Oka, T.; Yamamoto, M.; Yokoyama, M.; Ogawa, S.; Hansman, G. S.; Katayama, K.; Miyashita, K.; Takagi, H.; Tohya, Y.; Sato, H.; Takeda, N.. Highly conserved configuration of catalytic amino acid residues among calicivirus-encoded proteases,J. Virol., 2007, 81, 6798-6806.
84. Okamoto, M.; Takayama, K.; Shimizu, T.; Ishida, K.; Takahashi, O.; Furuya, T.. Identification of Death-Associated Protein Kinases Inhibitors Using Structure-Based Virtual Screening,J. Med. Chem., 2009, 52, 7323-7327.
85. Okazaki, S.; Suzuki, A.; Komeda, H.; Yamaguchi, S.; Asano, Y.; Yamane, T.. Crystal Structure and Functional Characterization of a D-Stereospecific Amino Acid Amidase fromOchrobactrum anthropi SV3, a New Member of the Penicillin-recognizing Proteins, J. Mol. Biol., 2007, 368, 79-91.
86. Okazaki, S.; Suzuki, A.; Mizushima, T.; Kawano, T.;Komeda, H.; Asano, Y.; Yamane, T.. The Novel Structure of a Pyridoxal 5′-Phosphate-Dependent Fold-Type I Racemase, α-Amino-ε-caprolactam Racemase from Achromobacter obae, Biochemistry, 2009, 48, 941-950.
87. 大川原　正、岡本良成、大塚雅巳 「薬剤耐性克服と創薬-イマチニブの耐性克服をどうするか」癌治療と宿主、2005, vol.17 No.2, p63(157)-71(165)
88. Pan, L.; Wen, Z.; Baudry, J.; Berenbaum, M.R.; Schuler, M.A.. Identification of Variable Amino Acids in the SRS1 Region of CYP6B1 Modulating Furanocoumarin Metabolism, Arch. Biochem. Biophys., 2004, 422, 31-41.
89. Rose, S. Statistical design and application to combinatorial chemistry, Drug Discovery Today, 2002, 7, 133-138.
90. Rupasinghe, S.; Baudry, J.; Schuler, M.A.. Common active site architecture and binding strategy of four phenylpropanoid P450s from Arabidopsis thaliana as revealed by molecular modeling, Protein Eng., 2003, 16, 721-731.
91. Song, H.; Nakayama, E. E.; Yokoyama, M.; Sato, H.; Levy, J. A.; Shioda, T.. A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5as, J. Virol., 2007, 81, 7280-7285.
92. Sato, F.; Hojo, S.; Sun, H. On the Transferability of Force Field Parameters-With an ab Initio Force Field Developed For Sulfonamides, J. Phys. Chem. A , 2003, 107, 248-257.
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95. Shirakawa, K.; Takaori-kondo, A.; Yokoyama, M.; Izumi, T; Matsui, M.; Io, K.; Sato, T.; Sato, H.; Uchiyama, T.. Protein kinase A-mediated phosphorylation regulates the interaction between APOBEC3G and HIV-1 Vif, Nat. Struct. Mol. Biol., 2008, 15, 1184-1191.
96. Soderling, S.H.; Beavo, J.A.. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions, Current Opinion in Cell Biology, 2000, 12, 174-179.
97. Song, M.; Breneman, C.M.; Bi, J.; Sukumar, N.; Bennett, K.P.; Cramer, S.; Tugcu, N.. Prediction of protein retention times in anion-exchange chromotography systems using support vector regression, J. Chem. Inf. Comput. Sci., 2002, 42, 1347-1357.
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